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Search Results for " axl receptor tyrosine kinase "

Targets Recommended: Discoidin Domain Receptor (DDR) VEGFR FLT Trk receptor TAM Receptor c-Kit Ephrin Receptor

11

抑制剂 & 化合物

1

天然产物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4349	Sitravatinib MG516,MGCD516	Discoidin Domain Receptor (DDR); VEGFR; FLT; Trk receptor; TAM Receptor; c-Kit; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Sitravatinib (MGCD516) 是一种有口服活性的受体酪氨酸激酶抑制剂。它单独使用即具有有效的抗肿瘤功效，且通过促进抗肿瘤免疫微环境增强了 PD-1 阻断的活性。
T4409	Gilteritinib 吉列替尼,ASP2215	FLT; TAM Receptor; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50:0.29 nM)，也是一种 AXL 抑制剂 (IC50:0.73 nM)，具有 ATP 竞争性。
T2586	Cabozantinib 卡博替尼,XL184,BMS-907351	Apoptosis; VEGFR; FLT; c-Met/HGFR; c-RET; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib (XL184) 是一种多靶点酪氨酸激酶受体抑制剂，可以抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM)。Cabozantinib 具有抗肿瘤和抗血管生成活性。
T5164	Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼	VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂，可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4（IC50：0.035、1.3、4.6、7 和 6 nM）。
T9052	XL092 CL-092,JUN04542	VEGFR; c-Met/HGFR; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	XL092 (JUN04542) 是一种ATP 竞争性的、口服有效的多受体酪氨酸激酶 (RTKs) 抑制剂，在细胞分析中的MET (IC50:15 nM)、VEGFR2 (IC50:1.6 nM)、AXL (IC50:3.4 nM) 和 MER (IC50:7.2 nM)。它具有抗肿瘤作用，具有用于研究激酶依赖性疾病的潜力。
T1797	Cabozantinib S-malate 苹果酸卡博替尼,Cabozantinib,卡博替尼苹果酸盐,XL184,Cabozantinib Malate	Apoptosis; VEGFR; c-Met/HGFR; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib S-malate (XL184) 是一种多受体酪氨酸激酶抑制剂，抑制VEGFR2，c-Met，Kit，Axl 和Flt3的IC50分别为0.035，1.3，4.6，7 和 11.3 nM。
T79969	Axl-IN-16	TAM Receptor	Tyrosine Kinase/Adaptors
	Axl-IN-16为Axl与HIF的双效抑制剂，能激发Flammulina velutipes子实体生成，并抑制HIF活性与受体酪氨酸激酶的表达。
T72574	Axl/Mer/CSF1R-IN-1
	Axl/Mer-IN-1 是一种 Axl/Mer 受体酪氨酸激酶 (Axl/Mer RTK) 和CSF1R 抑制剂，Kd 值均小于 0.1 μM。
T77085	Mipasetamab
	Mipasetamab 是一种靶向AXL 的 IgG1κ 抗体，AXL 是一种酪氨酸激酶受体，或者是 TAM 受体 (TAM Receptor)。 Mipasetamab 参与 ADCT-601 (Mipasetamab uzoptirine) 的合成，这是一种 AXL 靶向的抗体-活性分子偶联物 (ADC)。ADCT-601 具有抗肿瘤作用。
T80609	Mecbotamab
	Mecbotamab是一款针对AXL受体酪氨酸激酶的人源化IgG1-κ抗体。作为条件活性生物制剂(CAB)，Mecbotamab通过一个可降解连接子与MMAE结合，组成ADC（抗体-药物偶联物）产品Mecbotamab vedotin (BA3011)。
T12925	Sitravatinib malate MGCD516 malate,MG-516 malate	TAM Receptor	Tyrosine Kinase/Adaptors
	Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.) , shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

化合物

Cat.No: T4349

Synonym: MG516,MGCD516

Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor

Cat.No: T4409

Synonym: 吉列替尼,ASP2215

Target: FLT, TAM Receptor, c-Kit

Cat.No: T2586

Synonym: 卡博替尼,XL184,BMS-907351

Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit

Cabozantinib hydrochloride

Cat.No: T5164

Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼

Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR

Cat.No: T9052

Synonym: CL-092,JUN04542

Target: VEGFR, c-Met/HGFR, TAM Receptor

Cabozantinib S-malate

Cat.No: T1797

Synonym: 苹果酸卡博替尼,Cabozantinib,卡博替尼苹果酸盐,XL184,Cabozantinib Malate

Target: Apoptosis, VEGFR, c-Met/HGFR, TAM Receptor, c-Kit

Cat.No: T79969

Target: TAM Receptor

Axl/Mer/CSF1R-IN-1

Cat.No: T72574

Cat.No: T77085

Cat.No: T80609

Sitravatinib malate

Cat.No: T12925

Synonym: MGCD516 malate,MG-516 malate

Target: TAM Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。

天然产物

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01601	AXL Protein, Human, Recombinant (His) UFO,ARK,JTK11,AXL receptor tyrosine	Human	HEK293 Cells
	AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.
TMPY-06552	AXL Protein, Rat, Recombinant (His) AXL receptor tyrosine kinase<...	Rat	HEK293 Cells
	AXL Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.72 kDa and the accession number is Q8VI99.
TMPY-01021	AXL Protein, Mouse, Recombinant (His & hFc) AI323647,AXL receptor tyrosine	Mouse	HEK293 Cells
	AXL Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is Q00993.
TMPJ-00399	AXL Protein, Mouse, Recombinant (hFc) Tyrosine-protein kinase receptor ...	Mouse	HEK293 Cells
	AXL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is Q00993.
TMPJ-00449	AXL Protein, Human, Recombinant (hFc) UFO,Tyrosine-protein kinase receptor	Human	HEK293 Cells
	AXL Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-115 KDa and the accession number is AAA61243.
TMPY-06478	AXL Protein, Human, Recombinant (mFc) UFO,JTK11,ARK,Tyro7,AXL receptor tyros...	Human	HEK293 Cells
	AXL Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 72.11 kDa and the accession number is AAH32229.1.
TMPY-01364	AXL Protein, Mouse, Recombinant (His) Ark,AXL receptor tyrosine kin...	Mouse	HEK293 Cells
	AXL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.8 kDa and the accession number is Q00993.
TMPJ-00365	GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated AXLLG,Growth arrest-specific protein 6,AXL...	Human	HEK293 Cells
	Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, plat...
TMPK-00410	AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated ARK,EC 2.7.10.1,EC 2.7.10,Axl,JTK11,AXL on...	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein (Primary Amine Labeling), Human, Rec...
TMPK-00407	AXL Protein, Human, Recombinant (His & Avi) AXL oncogene,Axl,EC 2.7.10.1,Tyro7,UFO,ARK...	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is e...
TMPK-00472	AXL Protein, Cynomolgus, Recombinant (His) Tyro7,JTK11,AI323647,AXL oncogene,EC 2.7.10.1,EC 2....	Cynomolgus	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Cynomolgus, Recombinant (His) is ex...
TMPK-00408	AXL Protein, Human, Recombinant (His & Avi), Biotinylated AXL oncogene,EC 2.7.10.1,AI323647,Axl,JTK1...	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi), Bio...
TMPJ-00366	GAS6 Protein, Human, Recombinant (hFc) AXLLG,Gas6,GAS-6,AXLLGAXL stimula...	Human	HEK293 Cells
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...
TMPY-04999	GAS6 Protein, Human, Recombinant (His)	Human	HEK293
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...
TMPJ-01081	Dtk Protein, Human, Recombinant (His) RSE,SKY,DTK,Tyrosine-protein kinase DTK,	Human	HEK293 Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th...
TMPJ-01143	MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) MER,Receptor tyrosine kinase MerT...	Human	HEK293 Cells
	Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that t...

重组蛋白

AXL Protein, Human, Recombinant (His)

Cat.No: TMPY-01601

Species: Human

Expression System: HEK293 Cells

AXL Protein, Rat, Recombinant (His)

Cat.No: TMPY-06552

Species: Rat

Expression System: HEK293 Cells

AXL Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-01021

Species: Mouse

Expression System: HEK293 Cells

AXL Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00399

Species: Mouse

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00449

Species: Human

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (mFc)

Cat.No: TMPY-06478

Species: Human

Expression System: HEK293 Cells

AXL Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01364

Species: Mouse

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00365

Species: Human

Expression System: HEK293 Cells

AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00410

Species: Human

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00407

Species: Human

Expression System: HEK293 Cells

AXL Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00472

Species: Cynomolgus

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00408

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00366

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Human, Recombinant (His)

Cat.No: TMPY-04999

Species: Human

Expression System: HEK293

Dtk Protein, Human, Recombinant (His)

Cat.No: TMPJ-01081

Species: Human

Expression System: HEK293 Cells

MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)

Cat.No: TMPJ-01143

Species: Human

Expression System: HEK293 Cells

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